Stearylated octaarginine
網頁2024年4月30日 · In the last few years, a new stearylated peptide, STR-KV (STR-HHHKKKVVVVVV) has been developed and shown to cross the plasma membrane through a direct translocation pathway, achieving an 80% to 87% gene knockdown in three different cell lines [ 109 ].
Stearylated octaarginine
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網頁Stearylated octaarginine and artificial virus-like particles for transfection of siRNA into primary rat neurons. RNA 12: 1431–1438. Morris, MC, Vidal, P, Chaloin, L, Heitz, F and Divita, G (1997). 網頁2011年1月5日 · In this report, we employed octaarginine (R8) as a typical arginine-rich CPP and evaluated the effect of acylation using butanoic, hexanoic and decanoic acids on its capacity as a delivery vector. Hexanoyl octaarginine (C6R8-Alexa) showed the highest efficiency of cellular uptake of the studied variants, ten times higher than R8-Alexa.
網頁octaarginine, the gene transfer processes mediated by octaarginine or stearyl-octaarginine were compared. Both octaarginine and stearyl-octaarginine areable … 網頁2006年2月10日 · Preparation and Characterization of Octaarginine-modified Liposomes—A series of R8-Lip containing various concentrations of STR-R8 peptide was prepared. In …
網頁In the case of the Tat, FHV, and octaarginine peptides, N-terminal stearylation of the peptides increases the transfection efficiency by approximately 100 times to reach the same order of magnitude as that of LipofectAMINE, one of the most efficient commercially available transfection agents. Also, a certain correlation was observed between the ... 網頁Stearylated octaarginine (Stearyl-R8), are able to encapsulate and shuttle nucleic acids through cell membranes without the need to covalently attach the nucleic acid to the …
網頁2005年9月14日 · Stearyl octaarginine (STR-R8) was synthesized as described previously ( Futaki et al., 2001 ). Protamine sulfate salmon milt was purchased from Merck KGaA (Darmstadt, Germany). Lipofectamine 2000 was obtained from …
網頁2008年8月19日 · Background: Low transfection efficiency is an obstacle to the clinical use of non-viral gene vectors.Effective non-viral vectors require the ability to control intracellular trafficking of gene vectors for the delivery of exogenous DNA to the nucleus. Objective: To overcome multiple intracellular barriers, various types of devices must be integrated into … korean fonts for windows網頁It consists of a condensed DNA/polycation core and a lipid bilayer membrane envelope. Its surface is further modified with the membrane penetrating peptide stearylated octaarginine to improve... korean folk town to ludi網頁National Center for Biotechnology Information manfred niehues horstmar網頁2004年2月19日 · Octaarginine is able to translocate through cell membranes in a manner that does not exactly involve the classical endocytic pathways of internalization. However, when a stearyl moiety is... manfred nitsch網頁2006年8月1日 · Stearylated octaarginine (Stearyl-R8) was used as polypeptide and artificial virus-like particles (AVPs) were used as a combined liposomal-polymeric vector, since both reagents have been... manfred nowotny網頁Preparation and Characterization of Octaarginine-modified Liposomes—A series of R8-Lip containing various concentrations of STR-R8 peptide was prepared. In this preparation, … korean fonts microsoft word網頁2013年7月13日 · Here, we incorporated αGC into stearylated octaarginine-modified liposomes (R8-Lip), our original delivery system developed for vaccines, and investigated … korean font in photoshop