Nrf2 ferritin
Web24 mrt. 2024 · Oxidative stress and oxidative damage are the common pathophysiological characteristics in pituitary adenomas (PAs), which have been confirmed with many omics …
Nrf2 ferritin
Did you know?
Web1 jan. 2024 · Additionally, the expressions of ferroptosis-related proteins, NF-E2-related factor 2 (Nrf2), ferritin heavy chain 1 (FTH1), heme oxygenase 1 (HO-1), and glutathione peroxidase 4 (GPX4) were ... Web24 mrt. 2024 · Oxidative stress and oxidative damage are the common pathophysiological characteristics in pituitary adenomas (PAs), which have been confirmed with many omics studies in PA tissues and cell/animal experimental studies. Nuclear factor erythroid 2 p45-related factor 2 (Nrf2), the core of oxidative stress response, is an oxidative stress …
Web15 aug. 2024 · It has been reported that Nrf2 can mediate the expression of both ferritin and Fpn1 [23,24]. There is an ARE motif at 4 kb upstream of the transcription initiation … WebAntioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription.
Web11 jan. 2024 · Nrf2 is the central player in the regulation of antioxidant molecules [36] and is critical in mitigating lipid peroxidation and ferroptosis [37]. Nrf2 is degraded by Keap1 and Keap1 inhibition ... Web19 apr. 2024 · FIGURE 2.Mechanisms and key regulators of ferroptosis. The major mechanisms and key regulators of ferroptosis can be roughly divided into two important mechanisms (iron metabolism and lipid peroxidation) and seven key regulators (system Xc −, GPX4, p53, acyl-CoA synthetase long-chain family member 4 [ACSL4], FSP1, and …
Web1 jan. 2024 · LIP may be used for immediate biological processes including DNA synthesis, repair, and cell division, whereas unutilized LIP can be stored in ferritin (FT) [39]. The iron efflux protein FPN can export iron that isn't stored in the FT back into circulation (Fig. 1). Download : Download high-res image (764KB) Download : Download full-size image
Web8 jul. 2024 · Nrf2 inhibition promotes erastin-induced ferroptosis Given Nrf2 works as an important regulator in redox-dependent events and manipulates in cytoprotection, we hypothesized that Nrf2 affected erastin-induced ferroptosis in breast cancer. bthe-1sr-oWeb3 uur geleden · The authors first observed enhanced intracellular Fe 2+ levels and sensitivity to induced ferroptosis in NRF2-depleted ovarian carcinoma cells, associated with altered ferritin synthesis and ... bthe-1sr-lbWeb2 feb. 2024 · NRF2 and BACH1 activate and inhibit, respectively, labile iron metabolism, GSH-GPX4 pathway and FSP1-CoQ pathway. FTH1, ferritin heavy chain 1; FTL, … bthe-1srWeb1 mei 2024 · As a transcription factor, NRF2 regulated multiple genes constituting ferroptotic cascade, including but not limited to GPX4, SLC7A11, HO-1, the glutamate cysteine ligase, ferroportin, and ... exeter student houses to rentWebNrf2 restricts iron- or heme-mediated oxidative stress by regulating the expression of the FPN1, ferritin and HO-1 genes. Oxidative stress in the erythrocyte may be one of … bthe1sr-bWeb11 jan. 2024 · NRF2 is a stress-inducible transcription factor, whose protein levels are kept basally low by three different E3-ubiquitin ligase complexes: Kelch-like ECH-associated … exeter subaru used carsWeb1 sep. 2024 · Nrf2 is a crucial negative regulator of ferroptosis and acts through modulating various downstream genes, including SLC7A11, FTH1, and GPX4. ... Ferritin protects cells from oxidative stress-induced cell injury caused by redox active-free iron overload. exeter st sidwells point